2-甲氧基-5-硝基苯甲酸合成路线 （共 33 条）
反应条件
1: in methanol 12 h; Heating / reflux; 2: With hydrogenchloride in water T=20°C; pH=~ 2; 0.5 h;
参考文献
F2G LTD
Patent: WO2006/123145 A1, 2006 ;
Location in patent: Page/Page column 61-62 ;
反应条件
Nitroharnstoff; sulfuric acid T=25°C; 24 h;
参考文献
Almog, Joseph; Klein, Asne; Sokol, Anat; Sasson, Yoel; Sonenfeld, Dana; Tamiri, Tsippy
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8651 - 8652
反应条件
nitric acid T=5 - 10°C; 2 h; Yield given;
参考文献
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033
反应条件
sodium hydroxide in methanol 2 h; Heating;
参考文献
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033
反应条件
1: 18 percent / 10percent HNO3 / H2SO4 / 1 h / 5 °C 2: 95 percent / 2 N NaOH / methanol / 2 h / Heating View Scheme
参考文献
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033
反应条件
1: sulfuric acid / 21 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 60 °C 3: sodium hydroxide / methanol; water / 0.5 h / 60 °C View Scheme
参考文献
Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki
ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C 2: sodium hydroxide / methanol; water / 0.5 h / 60 °C View Scheme
参考文献
Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki
ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560
参考文献
Blanksma
Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 207,210
反应条件
1: aqueous hydrogen peroxide; potassium hydroxide 2: aqueous sulfuric acid; sodium nitrite View Scheme
参考文献
Dey; Doraiswami
Journal of the Indian Chemical Society, 1933 , vol. 10, p. 353,357
反应条件
1: hydrogen chloride; concentrated sulfuric acid 2: permanganate; acetone View Scheme
参考文献
Calvet; Mejuto
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1932 , vol. 30, p. 767,775
