4-(4-溴苯基)-1,2,3-噻二唑； 4-(4-溴苯基)-1,2,3-噻二唑合成路线 （共 8 条）
反应条件
1: With polystyrene-sulfonylhydrazide resin; acetic acid in tetrahydrofuran T=50°C; Solid phase reaction; 4 h; 2: With thionyl chloride in 1,2-dichloro-ethane T=60°C; Solid phase reaction; Hurd-Mori cyclization; 5 h;
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
thionyl chloride T=20 - 60°C; 4 h;
参考文献
Kumar, Anil; Muthyala, Manoj Kumar; Choudhary, Sunita; Tiwari, Rakesh K.; Parang, Keykavous
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9391 - 9396,6
反应条件
thionyl chloride T=0 - 20°C;
参考文献
Hayat, Faisal; Salahuddin, Attar; Zargan, Jamil; Azam, Amir
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 6127 - 6134
反应条件
1.1: tetrahydrofuran / 3 h / 0 °C 2.1: polystyrene-sulfonylhydrazide resin; acetic acid / tetrahydrofuran / 4 h / 50 °C 2.2: 96 percent / thionyl chloride / 1,2-dichloro-ethane / 5 h / 60 °C View Scheme
参考文献
Hu, Yonghan; Baudart, Sylvie; Porco Jr., John A.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1049 - 1051
反应条件
2: aq. HCl / methanol / 3 h / Heating 3: tBuOCl / CHCl3; dimethylformamide View Scheme
参考文献
Ege,G. et al.
Justus Liebigs Annalen der Chemie, 1977 , # 5 p. 791 - 799
反应条件
tert-butylhypochlorite in chloroform; N,N-dimethyl-formamide
参考文献
Ege,G. et al.
Justus Liebigs Annalen der Chemie, 1977 , # 5 p. 791 - 799
反应条件
1: aq. HCl / methanol / 3 h / Heating 2: tBuOCl / CHCl3; dimethylformamide View Scheme
参考文献
Ege,G. et al.
Justus Liebigs Annalen der Chemie, 1977 , # 5 p. 791 - 799
反应条件
thionyl chloride T=28°C; Rate constantMechanism;
参考文献
Butler, Richard N.; O'Donoghue, Denis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1223 - 1228
