5-氰基-2-甲氧基苯甲酸甲酯合成路线 （共 7 条）
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
T=100°C; P=3102.97 Torr; 4 h;
参考文献
Abbott Laboratories
Patent: US2008/287510 A1, 2008 ;
Location in patent: Page/Page column 24-25 ;
反应条件
thionyl chloride in dichloromethane
T=0°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 65; 67; 69 ;
US 20070249607 A1
反应条件
potassium carbonate in acetone
T=65°C;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/70195 A1, 2006 ;
Location in patent: Page/Page column 146-147 ;
WO 2006/070195 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP1698618 A1, 2006 ;
Location in patent: Page/Page column 56-57 ;
反应条件
sodium azide; CuSO4‵5H2O; [bis(acetoxy)iodo]benzene in acetonitrile
T=-40 - 25°C; Inert atmosphere;
参考文献
Zhou, Wang; Zhang, Liangren; Jiao, Ning
Angewandte Chemie, International Edition, 2009 , vol. 48, # 38 p. 7094 - 7097
Angewandte Chemie, 2009 , vol. 121, # 38 p. 7228 - 7231
反应条件
ferrous acetate in 1,2-dichloro-ethane
T=70°C; 48 h; Inert atmosphereSealed tube; regioselective reaction;
参考文献
Shu, Zhibin; Ji, Wenzhi; Wang, Xi; Zhou, Yujing; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2014 , vol. 53, # 8 p. 2186 - 2189
Angew. Chem., 2014 , vol. 53, # 8 p. 2218 - 2221,4
反应条件
1: With sodium hydroxide; water in dimethyl sulfoxide
T=80°C; 4.5 h;
2: With hydrogenchloride; water in dimethyl sulfoxide
T=0°C; pH=~ 4;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP1698618 A1, 2006 ;
Location in patent: Page/Page column 57-58 ;
