2,4-二羟基-3-丙基苯乙酮合成路线 （共 26 条）
反应条件
1: 47 percent / K2CO3, KI / acetone / 18 h / Heating 2: 39 percent / NaHCO3 / ethanol; H2O / 18 h / Heating View Scheme
参考文献
Marshall; Goodson; Cullinan; Swanson-Bean; Haisch; Rinkema; Fleisch
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 682 - 689
反应条件
1: 92 percent / K2CO3 / acetone / 12 h / Heating 2: 82 percent / CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Brown, Frederick J.; Bernstein, Peter R.; Cronk, Laura A.; Dosset, David L.; Hebbel, Kevin C.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 811 - 826
反应条件
1: K2CO3 / dimethylformamide 2: 95 percent / NaI / acetone / Heating 3: 62 percent / K2CO3 / dimethylformamide 4: 70 percent / H2, AcOH / 5percent Pd/C / 75 °C / 3102.9 Torr 5: K2CO3 / dimethylformamide 6: LiOH / methanol; H2O View Scheme
参考文献
Djuric; Collins; Jones; Shone; Tsai; Fretland; Butchko; Villani-Price; Keith; Zemaitis; Metcalf; Bauer
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1145 - 1147
参考文献
Lilly Industries Limited
Patent: US4513005 A1, 1985 ;
参考文献
Merck Frosst Canada Inc.
Patent: US4609744 A1, 1986 ;
反应条件
potassium carbonate in acetone
参考文献
Hoffmann-La Roche Inc.
Patent: US4628115 A1, 1986 ;
反应条件
potassium carbonate in acetone
参考文献
Hoffmann-La Roche Inc.
Patent: US4672066 A1, 1987 ;
US 4672066 A
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=75°C; 12 h;
参考文献
LeMahieu; Carson; Han; Nason; O'Donnell; Brown; Crowley; Welton
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 173 - 178
反应条件
potassium carbonate; potassium iodide in acetone
18 h; Heating;
参考文献
Marshall; Goodson; Cullinan; Swanson-Bean; Haisch; Rinkema; Fleisch
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 682 - 689
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Hoffmann-La Roche Inc.
Patent: US4507498 A1, 1985 ;
