乙基3-(4-联苯基)丙酸酯合成路线 （共 7 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol T=25°C; 20 h;
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=25°C;
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
反应条件
tributyl-amine; tetrabutyl-ammonium chloride; palladium diacetate in N,N-dimethyl-formamide
T=90°C; 50 h;
参考文献
Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta
Synlett, 2003 , # 8 p. 1133 - 1136
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.58 h / -78 °C
1.2: 83 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 90 percent / H2 / Pd/C / ethanol / 25 °C
View Scheme
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Nagano,R. et al.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 653 - 655
反应条件
diisobutylaluminium hydride in hexane; dichloromethane
T=-78°C; 2 h;
参考文献
Kimball, F. Scott; Romero, F. Anthony; Ezzili, Cyrine; Garfunkle, Joie; Rayl, Thomas J.; Hochstatter, Dustin G.; Hwang, Inkyu; Boger, Dale L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 937 - 947
反应条件
lithium borohydride in tetrahydrofuran
T=20°C; 48 h;
参考文献
Kimball, F. Scott; Romero, F. Anthony; Ezzili, Cyrine; Garfunkle, Joie; Rayl, Thomas J.; Hochstatter, Dustin G.; Hwang, Inkyu; Boger, Dale L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 937 - 947
