2-(1,3-苯并二氧代-5-基)-1-苯基-1-乙酮合成路线 （共 13 条）
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; sodium t-butanolate in 1,4-dioxane
T=90°C; 18 h; Inert atmosphereSealed tube;
参考文献
Crawford, Sarah M.; Alsabeh, Pamela G.; Stradiotto, Mark
European Journal of Organic Chemistry, 2012 , # 30 p. 6042 - 6050,9
反应条件
sodium ethanolate in ethanol
T=50°C; Substitution; 48 h;
参考文献
Angle, Steven R.; Neitzel, Martin L.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6458 - 6461
反应条件
1: ethanol / 0.67 h / 20 °C
2: EtONa / ethanol / 48 h / 50 °C
View Scheme
参考文献
Angle, Steven R.; Neitzel, Martin L.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6458 - 6461
反应条件
1: 1.) n-BuLi / 1.) THF, 0 deg C, 1 h, 2.) benzene, RT, 2 h
2: 80 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2 / 0 °C
3: 5 percent Spectr. / 1.) MgBr2, 2.) n-BuLi / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 10 min, 2a.) -78 deg C, 15 min, 2b.) -78 deg C to 25 deg C, 50 min
View Scheme
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
1: 1.) n-BuLi / 1.) THF, 0 deg C, 1 h, 2.) benzene, RT, 2 h
2: 80 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2 / 0 °C
3: 5 percent Spectr. / 1.) MgBr2, 2.) n-BuLi / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 10 min, 2a.) -78 deg C, 15 min, 2b.) -78 deg C to 25 deg C, 50 min
View Scheme
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
1: 95 percent / benzene / Heating
2: 1.) n-BuLi / 1.) THF, 0 deg C, 1 h, 2.) benzene, RT, 2 h
3: 80 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2 / 0 °C
4: 5 percent Spectr. / 1.) MgBr2, 2.) n-BuLi / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 10 min, 2a.) -78 deg C, 15 min, 2b.) -78 deg C to 25 deg C, 50 min
View Scheme
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
n-butyllithium; magnesium bromide in tetrahydrofuran; diethyl ether
1.) -78 deg C, 10 min, 2a.) -78 deg C, 15 min, 2b.) -78 deg C to 25 deg C, 50 min;
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
1: 80 percent / Na2CO3, m-chloroperbenzoic acid / CH2Cl2 / 0 °C
2: 5 percent Spectr. / 1.) MgBr2, 2.) n-BuLi / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 10 min, 2a.) -78 deg C, 15 min, 2b.) -78 deg C to 25 deg C, 50 min
View Scheme
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
1: 61 percent / tetrahydrofuran / Ambient temperature; or in DME
2: 1.) BuLi/ hexane / 1.) DME, 0 deg C, 30 min, 2.) r.t., 45 min
View Scheme
参考文献
Babudri; Fiandanese; Musio; Naso; Sciavovelli; Scilimati
Synthesis, 1991 , # 3 p. 225 - 228
反应条件
n-butyllithium; hexane
1.) DME, 0 deg C, 30 min, 2.) r.t., 45 min; Yield given. Multistep reaction;
参考文献
Babudri; Fiandanese; Musio; Naso; Sciavovelli; Scilimati
Synthesis, 1991 , # 3 p. 225 - 228
