1-(4-硝基苯基)环丙烷甲腈合成路线 （共 6 条）
反应条件
sulfuric acid; water Heating / reflux;
参考文献
WO2005/34837 A2, ;
Page/Page column 46 ;
WO 2005/034837 A2
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; acetonitrile
T=17 - 50°C; 1 h;
参考文献
CARDIOME PHARMA CORPORATION
Patent: WO2005/34837 A2, 2005 ;
Location in patent: Page/Page column 46 ;
WO 2005/034837 A2
反应条件
sodium nitrate; sulfuric acid
T=0 - 20°C;
参考文献
CADILA HEALTHCARE LIMITED; PANDYA, Vrajesh, B.; PARMAR, Bhavesh, M.
Patent: WO2011/61760 A1, 2011 ;
Location in patent: Page/Page column 18 ;
WO 2011/061760 A1
反应条件
1: potassium hydroxide; tetrabutylammomium bromide / water / 1 h / 50 °C
2: sodium nitrate; sulfuric acid / 0 - 20 °C
View Scheme
参考文献
CADILA HEALTHCARE LIMITED; PANDYA, Vrajesh, B.; PARMAR, Bhavesh, M.
Patent: WO2011/61760 A1, 2011 ;
WO 2011/061760 A1
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99276 A1, 2003 ;
Location in patent: Page 233, 235 ;
WO 03/099276 A1
反应条件
borane-THF in tetrahydrofuran
Heating / reflux;
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 90 ;
