4-甲基-5-羟基呋喃-2-酮合成路线 （共 22 条）
反应条件
morpholine in 1,4-dioxane; water
参考文献
LUPIN LIMITED; ROY, Bhairab, Nath; SINGH, Girij, Pal; LATHI, Piyush, Suresh; MITRA, Rangan
Patent: WO2012/7814 A2, 2012 ;
Location in patent: Page/Page column 21-22 ;
反应条件
hydrogenchloride in 1,4-dioxane; aqueous sodium chloride; ethyl acetate
参考文献
Ortho Pharmaceutical Corporation
Patent: US5464865 A1, 1995 ;
US 5464865 A
反应条件
morpholine hydrochloride in 1,4-dioxane; water 1) RT, 1 h, 2) 24 h, reflux;
参考文献
Bourguignon, J. J.; Wermuth, C. G.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894
反应条件
hydrogenchloride; iodine 3 h; Heating;
参考文献
Yamano, Yumiko; Fujita, Yumi; Mizuguchi, Yukari; Nakagawa, Kimie; Okano, Toshio; Ito, Masayoshi; Wada, Akimori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 9 p. 1365 - 1370
反应条件
1: 78 percent / dimethyldioxirane / acetone; CH2Cl2 2: 81 percent / H2O, Amberlyst-15 / Ambient temperature View Scheme
参考文献
Boukouvalas, John; Lachance, Nicolas
Synlett, 1998 , # 1 p. 31 - 32
反应条件
sodium tetrahydroborate in tetrahydrofuran THF, 0 deg C, 45 min; room temperature, 45 min;
参考文献
Johnson, Alan W.; Gowda, Gopala; Hassanali, Ahmed; Knox, John; Monaco, Sam; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1734 - 1743
反应条件
hydrogenchloride 0.25 h; Heating; Yield given;
参考文献
Bourguignon, J. J.; Wermuth, C. G.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894
反应条件
hydrogenchloride 0.25 h; Heating; Yield given;
参考文献
Bourguignon, J. J.; Wermuth, C. G.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894
反应条件
sulfuric acid; toluene-4-sulfonic acid Multistep reaction. Yields of byproduct given;
参考文献
Laugraud, Sylvain; Guingant, Andre; d'Angelo, Jean
Journal of Organic Chemistry, 1987 , vol. 52, # 21 p. 4788 - 4790
反应条件
1: 1.) NaH / 1.) HMPA, 0 deg C, 1 h, 2.) 20 min 2: 1.) ethylmagnesium bromide / 1.) THF, room temperature, 1 h, 2.) 15 min 3: 75 percent / DIBAH / tetrahydrofuran; toluene / 0.5 h / -78 °C 4: 90 percent / H2 / Lindlar catalyst / methanol / 24 h 5: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature 6: 90 percent / LiAlH4, TiCl3 / tetrahydrofuran / 0.5 h / Ambient temperature 7: sodium fluoride, pyridinium fluoride / tetrahydrofuran; acetonitrile / 5 h / Ambient temperature 8: MnO2 / CCl4 / 0.5 h 9: 60 percent / NaCN, AgO, MnO2 / 14 h / 40 °C 10: 70 percent / 6 M NaOH / ethanol / 50 °C View Scheme
参考文献
Solladie; Girardin; Metra
Tetrahedron Letters, 1988 , vol. 29, # 2 p. 209 - 212
