1.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere 3.1: hydrogenchloride / ethanol; water / 6 h / 90 °C View Scheme

1.1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 2.2: -78 - 20 °C / |Inert atmosphere 3.1: dichloromethane 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme

sodium hydroxide in ethanol Heating;

1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 74 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 82 percent / NaOH / ethanol / Heating View Scheme

1.1: NaH / tetrahydrofuran / 20 °C 1.2: 95 percent / tetrahydrofuran / 8 h / 20 °C 2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 74 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C 3.1: 82 percent / NaOH / ethanol / Heating View Scheme