(S)-(-)-alpha-(Boc-氨基)-gamma-丁酸内酯合成路线 （共 14 条）
反应条件
4-(N,N-dimethlyamino)pyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran T=23°C; 16 h;
参考文献
Stachel; Chul Bom Lee; Spassova; Chappell; Bornmann; Danishefsky; Chou; Guan
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4369 - 4378
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 20 h;
参考文献
Biel, Markus; Deck, Patrick; Giannis, Athanassios; Waldmann, Herbert
Chemistry - A European Journal, 2006 , vol. 12, # 15 p. 4121 - 4143
反应条件
boron trifluoride diethyl etherate; 2,2-dimethoxy-propane in acetone T=20°C; 24 h;
参考文献
De Jonghe, Steven; Lamote, Inge; Venkataraman, Krishnan; Boldin, Swetlana A.; Hillaert, Ulrik; Rozenski, Jef; Hendrix, Chris; Busson, Roger; De Keukeleire, Denis; Van Calenbergh, Serge; Futerman, Anthony H.; Herdewijn, Piet
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 988 - 996
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
Weitz, Iris S.; Pellegrini, Maria; Mierke, Dale F.; Chorev, Michael
Journal of Organic Chemistry, 1997 , vol. 62, # 8 p. 2527 - 2534
反应条件
montmorillonite K-10 in toluene T=65°C; 30 h;
参考文献
Hernandez, J. Nicolas; Crisostomo, Fernando R. Pinacho; Martin, Tomas; Martin, Victor S.
European Journal of Organic Chemistry, 2007 , # 30 p. 5050 - 5058
反应条件
triethylamine in dichloromethane 12 h; Ambient temperature;
参考文献
Berkowitz, David B.; Smith, Marianne K.
Synthesis, 1996 , # 1 p. 39 - 41
反应条件
triethylamine in dichloromethane T=0 - 20°C; 12 h;
参考文献
Clerc, Jerome; Li, Nan; Krahn, Daniel; Groll, Michael; Bachmann, Andre S.; Florea, Bogdan I.; Overkleeft, Herman S.; Kaiser, Markus
Chemical Communications, 2011 , vol. 47, # 1 p. 385 - 387
反应条件
1: 86 percent / 1 N NaOH / ethanol; H2O; tetrahydrofuran / 16 h / 23 °C 2: 84 percent / 1-hydroxybenzotriazole, 4-(dimethylamino)pyridine, DCC / tetrahydrofuran / 16 h / 23 °C View Scheme
参考文献
Baldwin, J. E.; Flinn, A.
Tetrahedron Letters, 1987 , vol. 28, # 31 p. 3605 - 3608
反应条件
1: With sodium hydroxide in water; acetonitrile 2: With methyl iodide in tetrahydrofuran 3: With sodium hydroxide in ethyl acetate Further stages.;
参考文献
Janey, Jacob M.; Orella, Charles J.; Njolito, Eugenia; Baxter, Jenny M.; Rosen, Jonathan D.; Palucki, Michael; Sidler, Rick R.; Li, Wenjie; Kowal, Jason J.; Davies, Ian W.
Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3212 - 3217
反应条件
triethylamine in dichloromethane T=20°C; 17 h; Inert atmosphere;
参考文献
Sanchez, Adrian; Calderon, Ernesto; Vazquez, Alfredo
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2012-M0583-OP, p. 1364 - 1372
