(S)-(-)-alpha-(Boc-氨基)-gamma-丁酸内酯合成路线 （共 14 条）
反应条件
citric acid continuous extraction into EtOAc; Yield given;
参考文献
Baldwin, J. E.; Flinn, A.
Tetrahedron Letters, 1987 , vol. 28, # 31 p. 3605 - 3608
反应条件
sodium tetrahydroborate; sulfuric acid; lithium bromide 1) diglyme, 110 deg C, 24 h, 2) 0 deg C to 40 deg C, water, CH2Cl2; Yield given. Multistep reaction;
参考文献
Uzar
Synthesis, 1991 , # 7 p. 526 - 528
反应条件
potassium hydroxide T=20°C; 12 h;
参考文献
Sanchez, Adrian; Calderon, Ernesto; Vazquez, Alfredo
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2012-M0583-OP, p. 1364 - 1372
反应条件
1: 2.63 g / aq. KOH / 1.) DMF, 0 deg C, 1 h then rt., 2 h; 2.) 18-crown-6, rt., 18 h
2: 82 percent / (COCl)2, DMSO, Et3N / CH2Cl2 / 2 h / -78 - 0 °C
View Scheme
参考文献
Matsuura; Hamada; Shioiri
Tetrahedron, 1994 , vol. 50, # 1 p. 265 - 274
