1: α-[(trimethylsilyl)oxy]-α-(o-methoxyphenyl)acetonitrile With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70°C; 0.5 h; 2: 1-bromo-3-chloro-propane in tetrahydrofuran; hexane T=20°C; 2 h; 3: With hydrogenchloride in methanol T=20°C; Further stages.;

ammonium chloride; iodine in tetrahydrofuran; hexane; water; ethyl acetate

1.1: ZnI2 2.1: diisopropylamine; n-butyl lithium / hexane; tetrahydrofuran / 0.5 h / -70 °C 2.2: tetrahydrofuran; hexane / 2 h / 20 °C 2.3: 44 percent / aq. HCl / methanol / 20 °C View Scheme

in tetrahydrofuran T=0°C;