Γ-氯-4-甲氧基苯丁酮合成路线 （共 16 条）
反应条件
1: methoxybenzene With AlCl3, aluminium chloride in toluene T=-10°C; 0.25 h; 2: γ-chlorobutyryl chloride in toluene T=-10°C; 0.75 h;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2006/32453 A1, 2006 ;
Location in patent: Page/Page column 20-21 ;
WO 2006/032453 A1
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 3 h;
参考文献
Rao, Maddali L.N.; Venkatesh, Varadhachari; Banerjee, Debasis
Tetrahedron, 2007 , vol. 63, # 52 p. 12917 - 12926
反应条件
iron silicate T=25°C; Friedel-Crafts acylation;
参考文献
Borate, Hanumant B.; Gaikwad, Abaji G.; Maujan, Suleman R.; Sawargave, Sangmeshwer P.; Kalal, Kamalakar M.
Tetrahedron Letters, 2007 , vol. 48, # 28 p. 4869 - 4872
反应条件
in tetrahydrofuran T=0°C;
参考文献
Pablo, Oscar; Guijarro, David; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9181 - 9189
反应条件
magnesium 1.) Et2O, 2.) Et2O, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Takeuchi, Ken'ichi; Kitagawa, Toshikazu; Miyabo, Atsushi; Hori, Hideshi; Komatsu, Koichi
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5802 - 5810
反应条件
sodium azide in N,N-dimethyl-formamide T=70°C; 4 h;
参考文献
Weinstein, David S.; Ngu, Khehyong; Robl, Jeffrey A.
Patent: US2005/70588 A1, 2005 ;
Location in patent: Page/Page column 14 ;
US 20050070588 A1
反应条件
palladium monocarbide in tetrahydrofuran
参考文献
Ikemoto, Tomomi; Ito, Tatsuya; Tomimatsu, Kiminori; Sawai, Yasuhiro; Nishiyama, Hirohiko; Isogami, Yasushi
Patent: US2003/69419 A1, 2003 ;
反应条件
potassium hydroxide in methanol 12 h; Ambient temperature;
参考文献
Takeuchi, Ken'ichi; Kitagawa, Toshikazu; Miyabo, Atsushi; Hori, Hideshi; Komatsu, Koichi
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5802 - 5810
反应条件
sodium hydrogencarbonate; toluene-4-sulfonic acid in ethylene glycol; toluene
参考文献
Herrmann, Andreas
Patent: US2003/129212 A1, 2003 ;
参考文献
Bristol-Myers Squibb Company
Patent: US6348472 B1, 2002 ;
Location in patent: Page column 10 ;
US 6348472 B1
