clostripain; sodium chloride; calcium chloride in acetate buffer T=25°C; Hydrolysis; acylation; pH=10.0; Enzymatic reaction; Product distribution;

hydrogen; iron(III) oxide in ethanol; ammonia T=90°C; P=157516 Torr; 4 h; Autoclave;

ammonia; hydrogen; Raney nickel in ethanol; water T=100 - 110°C; P=76005.1 - 114008 Torr; 4 h; Industry scale;

1: With ozone; potassium iodide in water; tert-butyl alcohol 1 h; 2: With ammonia; hydrogen T=80°C; P=52505.3 Torr; 6 h; Autoclave;

1.1: sulfuric acid / water / 6 h / Heating; Reflux; Industry scale 2.1: ozone; oxygen; acetic acid / 7 h / Cooling with water bath; Industry scale 2.2: Industry scale 3.1: hydrogen; ammonia / Raney nickel / ethanol; water / 4 h / 100 - 110 °C / 76005.1 - 114008 Torr / Industry scale View Scheme

1.1: ammonia / zinc oxide / 300 °C / 760.05 Torr / Gas phase 2.1: Grubb's 2nd generation catalyst / 60 °C / 760.05 Torr 3.1: ozone / pentane / 0.08 h / 5 °C 3.2: 4 h / 60 °C 4.1: sulfuric acid / benzene 5.1: hydrogen / iron(III) oxide / ethanol; ammonia / 4 h / 90 °C / 157516 Torr / Autoclave View Scheme

1.1: Grubb's 2nd generation catalyst / 60 °C / 760.05 Torr 2.1: ozone / pentane / 0.08 h / 5 °C 2.2: 4 h / 60 °C 3.1: sulfuric acid / benzene 4.1: hydrogen / iron(III) oxide / ethanol; ammonia / 4 h / 90 °C / 157516 Torr / Autoclave View Scheme

1: 97 percent / NaN3 / xylene / 2 h / 140 °C 2: conc. HCl / 2.5 h / Heating View Scheme

1: 98 percent / SOCl2 / 3 h / 50 °C 2: 97 percent / NaN3 / xylene / 2 h / 140 °C 3: conc. HCl / 2.5 h / Heating View Scheme

1.1: Grubb's 2nd generation catalyst / 6 h / 30 °C / 760.05 Torr 2.1: sulfuric acid / water / 6 h / Heating; Reflux; Industry scale 3.1: ozone; oxygen; acetic acid / 7 h / Cooling with water bath; Industry scale 3.2: Industry scale 4.1: hydrogen; ammonia / Raney nickel / ethanol; water / 4 h / 100 - 110 °C / 76005.1 - 114008 Torr / Industry scale View Scheme