2-甲基-4-o-甲苯基丁-3-炔-2-醇合成路线 （共 7 条）
反应条件
18-crown-6 ether; N,N'-(2,9-di-c-hexyl-10-phenanthryl)2-4,5-diHimidazolium hexafluorophosphate; potassium tert-butylate; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=65°C; Sonogashira coupling reaction; 3 h;
参考文献
Hundertmark, Thomas; Littke, Adam F.; Buchwald, Stephen L.; Fu, Gregory C.
Organic Letters, 2000 , vol. 2, # 12 p. 1729 - 1731
反应条件
copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=70°C; 2.5 h;
参考文献
Mori, Hajime; Matsuo, Takafumi; Yoshioka, Yasunori; Katsumura, Shigeo
Journal of Organic Chemistry, 2006 , vol. 71, # 24 p. 9004 - 9012
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
magnesium in tetrahydrofuran; methoxybenzene
T=40 - 45°C; 4 h;
参考文献
Shchelkunov; Sivolobova; Mataeva; Minbaev; Muldakhmetov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 1 p. 5 - 8
反应条件
1: 90.5 percent / chlorine; NaOH / H2O; benzene / 1 h / 20 °C
2: magnesium / methoxybenzene; tetrahydrofuran / 4 h / 40 - 45 °C
View Scheme
参考文献
Shchelkunov; Sivolobova; Mataeva; Minbaev; Muldakhmetov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 1 p. 5 - 8
反应条件
1: Cu, K2CO3, Py / 50 h
2: (acid hydrolysis)
View Scheme
参考文献
Moroz,A.A.; Shvartsberg,M.S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1973 , vol. 22, p. 464 - 466
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1973 , vol. 22, # 2 p. 476 - 479
参考文献
Moroz,A.A.; Shvartsberg,M.S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1973 , vol. 22, p. 464 - 466
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1973 , vol. 22, # 2 p. 476 - 479
