1-萘-3-甲基-1-丁炔-3-醇合成路线 （共 7 条）
反应条件
sodium hydroxide in toluene T=120°C; 0.5 h;
参考文献
Ube Industries, Ltd.
Patent: EP1847545 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tris(4-methylphenyl)-phosphine in tetrahydrofuran
T=80°C; Sonogashira Cross-Coupling; 6 h; Inert atmosphereSchlenk technique;
参考文献
Caporale, Andrea; Tartaggia, Stefano; Castellin, Andrea; De Lucchi, Ottorino
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 384 - 393
反应条件
piperidine; bis-triphenylphosphine-palladium(II) chloride in various solvent(s)
Sonogashira coupling; 2 h; Heating;
参考文献
Fukuyama, Takahide; Shinmen, Masutaka; Nishitani, Satoshi; Sato, Masaaki; Ryu, Ilhyong
Organic Letters, 2002 , vol. 4, # 10 p. 1691 - 1694
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Oi, Shuichi; Orihara, Hideki; Kawai, Hiroshi; Inoue, Yoshio
Heterocycles, 2005 , vol. 66, # 1 p. 621 - 625
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
1: Cu, K2CO3, Py
2: (acid hydrolysis)
View Scheme
参考文献
Moroz,A.A.; Shvartsberg,M.S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1973 , vol. 22, p. 464 - 466
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1973 , vol. 22, # 2 p. 476 - 479
参考文献
Moroz,A.A.; Shvartsberg,M.S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1973 , vol. 22, p. 464 - 466
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1973 , vol. 22, # 2 p. 476 - 479
