(2-甲氧基-5-硝基苯基)甲胺合成路线 （共 4 条）
反应条件
1: With triphenylphosphine in tetrahydrofuran
T=20°C; 12 h;
2: With hydrogenchloride in water
3: With sodium hydrogencarbonate in water
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
Location in patent: Page/Page column 56-58 ;
反应条件
1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C
2: triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
反应条件
1: sulfuric acid; sodium bromide; acetic acid / 20 h / 28 - 85 °C
2: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C
3: triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
反应条件
(i) hexamethylenetetramine, (ii) aq. HCl; Multistep reaction;
参考文献
Quelet,R.; Coudanne,H.
Bulletin de la Societe Chimique de France, 1963 , p. 2445 - 2449
