1: 70 percent / NaOEt / ethanol / -15 °C 2: 85 percent / CH2Cl2 / Ambient temperature 3: 85 percent / toluene / 12 h / 160 °C 4: 70 percent / HCOOH / Heating 5: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature 6: 98 percent / Ph2PON3, NEt3 7: 80 percent / HOAc / H2O View Scheme

1: 70 percent / NaOEt / ethanol / -15 °C 2: 85 percent / CH2Cl2 / Ambient temperature 3: 85 percent / toluene / 12 h / 160 °C 4: 70 percent / HCOOH / Heating 5: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587204', constants.ctx, '0')">tert.-butyl lithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br /> <br /> &nbsp;