暂无反应条件数据

in tetrahydrofuran T=-65 - 20°C;

lithium diisopropyl amide in tetrahydrofuran; hexane 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h;

1: 1.) tetra-n-butylammonium bisulfate, 50percent KOH / 1.) benzene, 5 min, 2.) 2 h 2: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h 3: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -70 °C View Scheme

1: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h 2: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -70 °C View Scheme

1: 1.) tetra-n-butylammonium bisulfate, 50percent KOH / 1.) benzene, 5 min, 2.) 2 h 2: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h 3: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -70 °C View Scheme

1: 1.) n-butyllithium / 1.) THF, hexane, from -78 deg C to 0 deg C, 1 h, 2.) from -78 deg C to room temp., overnight 2: lithium diisopropylamide / tetrahydrofuran; hexane / 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h View Scheme

Yield given. Multistep reaction;

in tetrahydrofuran T=-65 - 20°C;

1: 46 percent / tetrahydrofuran / 1) -78 deg C, 30 min, 2) room temperature, 4h 2: 64 percent / 80percent hydrazine hydrate, potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 6 h / 120 - 140 °C View Scheme