3-(4-甲氧羰苯基)丙酸甲酯合成路线 （共 7 条）
反应条件
1: With methanol; sodium hydroxide; water T=0 - 20°C; 16 h; 2: With hydrogenchloride in diethyl ether; water
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1593667 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
EP 1593667 A1
反应条件
bromine; iron in tetrachloromethane 16 h; Reflux;
参考文献
Pechlivanidis, Zissis; Hopf, Henning; Ernst, Ludger
European Journal of Organic Chemistry, 2009 , # 2 p. 223 - 237
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide
T=80°C;
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
palladium on activated charcoal; hydrogen in ethyl acetate
T=20°C;
参考文献
Pechlivanidis, Zissis; Hopf, Henning; Ernst, Ludger
European Journal of Organic Chemistry, 2009 , # 2 p. 223 - 237
反应条件
pyridine; Ni(PPh3)3Cl2; zinc in acetonitrile
T=65°C; 4 h;
参考文献
Lebedev, S. A.; Lopatina, V. S.; Petrov, E. S.; Beletskaya, I. P.
Journal of Organometallic Chemistry, 1988 , vol. 344, p. 253 - 260
反应条件
bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triphenylphosphine; nickel dichloride in tetrahydrofuran
T=50°C; 16 h; Inert atmosphere; Overall yield = 63 percent;
参考文献
Marquez, Irene R.; Miguel, Delia; Millan, Alba; Marcos, M. Luisa; De Cienfuegos, Luis Alvarez; Campana, Araceli G.; Cuerva, Juan M.
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1529 - 1541
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Kuwano, Satoru; Harada, Shingo; Oriez, Raphael; Yamada, Ken-Ichi
Chemical Communications, 2012 , vol. 48, # 1 p. 145 - 147
