1: water; potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine / 12 h / 70 °C / Inert atmosphere 3: 1 h / 50 °C / Inert atmosphere; Neat (no solvent); Sealed tube 4: zinc(II) chloride / 1,4-dioxane / 192 h / 100 °C / Inert atmosphere View Scheme

water; potassium carbonate in methanol T=20°C; 0.5 h; Inert atmosphere;

1: sodium hydroxide / methanol; water / 0.08 h / 20 °C 2: N-bromosuccinmide / tetrahydrofuran / 0.58 h / -78 °C / Inert atmosphere View Scheme