3-苄氧基-4-甲氧基苯酚合成路线 （共 9 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine / 12 h / 70 °C / Inert atmosphere 2: 1 h / 50 °C / Inert atmosphere; Neat (no solvent); Sealed tube 3: zinc(II) chloride / 1,4-dioxane / 192 h / 100 °C / Inert atmosphere View Scheme
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 2 h;
2: With ammonia in methanol
T=20°C;
参考文献
Kamiyama, Haruka; Kubo, Yoshinao; Sato, Hironori; Yamamoto, Naoki; Fukuda, Tsutomu; Ishibashi, Fumito; Iwao, Masatomo
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7541 - 7550
反应条件
water; potassium carbonate in methanol
T=20°C; 0.5 h; Inert atmosphere;
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
1: 82 percent / K2CO3 / dimethylformamide / 18 h / 20 °C
2: 84 percent / MCPBA / CH2Cl2 / 2 h / 20 °C
3: 79 percent / NaOMe; MeOH / 0.5 h / 20 °C
View Scheme
参考文献
Lawrence, Nicholas J.; Rennison, David; Woo, Meiki; McGown, Alan T.; Hadfield, John A.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 51 - 54
反应条件
1.1: potassium carbonate; sodium hydroxide / water / Inert atmosphere; Reflux
1.2: 1 h / Inert atmosphere; Reflux
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3.1: water; potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
1: 82 percent / K2CO3 / dimethylformamide / 18 h / 20 °C
2: 84 percent / MCPBA / CH2Cl2 / 2 h / 20 °C
3: 79 percent / NaOMe; MeOH / 0.5 h / 20 °C
View Scheme
参考文献
Lawrence, Nicholas J.; Rennison, David; Woo, Meiki; McGown, Alan T.; Hadfield, John A.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 51 - 54
反应条件
methanol; potassium carbonate
T=20°C; 1.5 h;
参考文献
Fukuda, Tsutomu; Ohta, Takeshi; Saeki, Sho; Iwao, Masatomo
Heterocycles, 2010 , vol. 80, # 2 p. 841 - 846
反应条件
water; N,N-dimethyl-formamide dimethyl acetal
T=90°C; 24 h;
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
N-bromosuccinmide in tetrahydrofuran
T=-78°C; 0.583333 h; Inert atmosphere;
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
