1: With sodium hydroxide; water
4 h; Heating / reflux;
2: With hydrogenchloride in water
Acidic aqueous solution;
3: With sodium hydrogencarbonate in water
Alkaline aqueous solution;
参考文献
WYETH
Patent: WO2008/52075 A2, 2008 ;
Location in patent: Page/Page column 81 ;
WO 2008/052075 A2