2-氨基-5-甲氧基苯酚合成路线 （共 31 条）
参考文献
Koyama et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1002,1004
Chem.Abstr., 1957 , p. 2738
参考文献
Koyama et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1002,1004
Chem.Abstr., 1957 , p. 2738
参考文献
Koyama et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1002,1004
Chem.Abstr., 1957 , p. 2738
Full Text Show Details
Hietala; Wahlroos
Acta Chemica Scandinavica (1947-1973), 1956 , vol. 10, p. 1196
反应条件
triethylamine in dichloromethane T=0 - 20°C; 5 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/15664 A1, 2007 ;
Location in patent: Page/Page column 19-20 ;
WO 2007/015664 A1
反应条件
1: (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C 2: NaOH / dimethylformamide / 5 h / 120 °C 3: NaH / dimethylformamide / Ambient temperature View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: diethyl ether / 24 h / 20 °C 2: 26 mg / aq. NaHCO3 / 0.5 h / Heating View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 54, # 4 p. 1064 - 1074
反应条件
in toluene
2 h; Heating;
参考文献
Loev, Bernard; Jones, Howard; Brown, Richard E.; Huang, Fu-chih; Khandawala, Atul; et. al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 24 - 27
反应条件
1: 73 percent / tetrahydrofuran / 0.5 h
2: 93 percent / Heating
View Scheme
参考文献
Hartenstein, H.; Sicker, D.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993 , vol. 335, # 4 p. 359 - 362
反应条件
pyridine
1.) 100 deg C, 1 h; 2.) 200 deg C, 0.5 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3168 - 3178
反应条件
in water
T=60°C; 1 h;
参考文献
ASTRAZENECA AB?
Patent: WO2005/49620 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/049620 A1
