对乙酰氨基-邻甲氧基苯甲酸甲酯合成路线 （共 45 条）
反应条件
potassium carbonate in acetone 8 h; Heating;
参考文献
MacKenzie, A. Roderick; Moody, Christopher J.; Rees, Charles W.
Tetrahedron, 1986 , vol. 42, # 12 p. 3259 - 3268
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide 2: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: 95.5 percent / K2CO3, tetra-n-butylammonium chloride / acetonitrile / 22 h / Heating 2: 94.9 percent / N-methylpyrrolidone / 1.5 h / Heating 3: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 4: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 5: NaBH4 / methanol / 2 h / 20 - 25 °C 6: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C View Scheme
参考文献
Kakigami, Takuji; Usui, Toshinao; Tsukamoto, Katsura; Kataoka, Tadashi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 42 - 52
反应条件
1: 95.5 percent / K2CO3, tetra-n-butylammonium chloride / acetonitrile / 22 h / Heating 2: 94.9 percent / N-methylpyrrolidone / 1.5 h / Heating 3: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 4: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 5: NaBH4 / methanol / 2 h / 20 - 25 °C 6: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 7: NCS / dimethylformamide / 3 h / 70 °C View Scheme
参考文献
Kakigami, Takuji; Usui, Toshinao; Tsukamoto, Katsura; Kataoka, Tadashi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 42 - 52
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide 2: N-bromosuccinmide / N,N-dimethyl-formamide View Scheme
参考文献
Deng, Xin; Zhao, Xinxin; Han, Jing; Wang, Jingjie; Huang, Wenlong; Qian, Hai; Ge, Liang
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 489 - 493
反应条件
1: 95.5 percent / K2CO3, tetra-n-butylammonium chloride / acetonitrile / 22 h / Heating 2: 94.9 percent / N-methylpyrrolidone / 1.5 h / Heating 3: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 4: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 5: NaBH4 / methanol / 2 h / 20 - 25 °C View Scheme
参考文献
Kakigami, Takuji; Usui, Toshinao; Tsukamoto, Katsura; Kataoka, Tadashi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 42 - 52
反应条件
1: 80 percent / SO2Cl2 / CHCl3 / 3 h / 25 °C 2: 77 percent / NaI, chloramine-T / dimethylformamide / 1 h / 10 °C 3: 62 percent / K2CO3 / acetone / 2 h / Heating 4: 70 percent / NaOH / ethanol / 0.5 h / 80 °C 5: 73 percent / NaOH / ethanol / 16 h / Heating View Scheme
参考文献
De Paulis, Tomas; Trivedi, Bakula L.; Zhang, Zhang-Jin; Schmidt, Dennis E.; Ebert, Michael H.; Hewlett, William A.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2657 - 2662
反应条件
N-chloro-succinimide in 1,2-dichloro-ethane 3 h; Reflux;
参考文献
WO2013/42135 A1, ;
Page/Page column 11 ;
反应条件
1: 97 percent / potassium carbonate / acetone / 8 h / Heating 2: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C 3: 80 percent / manganese (IV) oxide / CHCl3; methanol / 20 h / Ambient temperature 4: 73 percent / NaOMe / methanol / 2 h / -15 °C 5: 87 percent / xylene / 4 h / Heating 6: 85 percent / HCl / methanol / 6 h / Heating 7: 2.) HCl / 1.) CH2Cl2, room temp., 12 h; 2.) 12 h, ether 8: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h 9: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 42, # 12 p. 3259 - 3268
