6-溴-2-氯-3-乙基喹啉合成路线 （共 4 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=10 - 20°C; 2: N-(4-bromophenyl)butanamide T=85°C; Vilsmeier-Haack reaction; 4 h;
参考文献
Mabire, Dominique; Coupa, Sophie; Adelinet, Christophe; Poncelet, Alain; Simonnet, Yvan; Venet, Marc; Wouters, Ria; Lesage, Anne S. J.; Van Beijsterveldt, Ludy; Bischoff, Francois
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2134 - 2153
反应条件
1.1: 100 percent / Et3N / CH2Cl2 / 5 - 20 °C 2.1: POCl3 / 10 - 20 °C 2.2: 73 percent / 4 h / 85 °C View Scheme
参考文献
Mabire, Dominique; Coupa, Sophie; Adelinet, Christophe; Poncelet, Alain; Simonnet, Yvan; Venet, Marc; Wouters, Ria; Lesage, Anne S. J.; Van Beijsterveldt, Ludy; Bischoff, Francois
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2134 - 2153
反应条件
1: 6-bromo-2-chloro-3-ethylquinoline With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 1 h;
2: N,4-dimethoxy-N-cis/trans-methylcyclohexanecarboxamide in tetrahydrofuran; hexane
T=-70°C; 1 h;
参考文献
Mabire, Dominique; Coupa, Sophie; Adelinet, Christophe; Poncelet, Alain; Simonnet, Yvan; Venet, Marc; Wouters, Ria; Lesage, Anne S. J.; Van Beijsterveldt, Ludy; Bischoff, Francois
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2134 - 2153
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -70 °C
1.2: 67 percent / hexane; tetrahydrofuran / 1 h / -70 °C
2.1: 33 percent / KMnO4; TDA1 / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Mabire, Dominique; Coupa, Sophie; Adelinet, Christophe; Poncelet, Alain; Simonnet, Yvan; Venet, Marc; Wouters, Ria; Lesage, Anne S. J.; Van Beijsterveldt, Ludy; Bischoff, Francois
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2134 - 2153
