2-甲氧羰基琥珀酸二甲酯合成路线 （共 19 条）
反应条件
1: malonic acid dimethyl ester With sodium methylate in methanol T=0°C; 0.5 h; 2: bromoacetic acid methyl ester in methanol 4 h;
参考文献
Janza, Birgit; Studer, Armido
Organic Letters, 2006 , vol. 8, # 9 p. 1875 - 1878
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide 1 h; Heating;
参考文献
Brillon, Denis
Synthetic Communications, 1986 , vol. 16, # 3 p. 291 - 298
反应条件
dicobalt octacarbonyl T=90 - 110°C; P=147102 - 220652 Torr;
参考文献
Pino; Miglierina
Journal of the American Chemical Society, 1952 , vol. 74, p. 5551
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Pino et al.
Gazzetta Chimica Italiana, 1954 , vol. 84, p. 453,460
反应条件
1: malonic acid dimethyl ester; tert-Butyl-dimethyl-[1-((1S,6S)-2,4,4,6-tetramethyl-7-oxa-bicyclo[4.1.0]hept-2-yloxy)-vinyloxy]-silane With 1-azabicyclo[2.2.2]octane borane adduct; t-BuON=NOt-Bu in benzene T=70°C; 2: methyl iodide With tetrabutyl ammonium fluoride Further stages.;
参考文献
Cai, Yudong; Dang, Hai-Shan; Roberts, Brian P.
Tetrahedron Letters, 2004 , vol. 45, # 22 p. 4405 - 4409
反应条件
tris-(dibenzylideneacetone)dipalladium(0); methanesulfonic acid; α,α'-bis(di-t-butylphosphino)-o-xylene T=90°C; P=22502.3 Torr; 24 h; AutoclaveInert atmosphereSchlenk technique;
参考文献
Furst, Marc R. L.; Seidensticker, Thomas; Cole-Hamilton, David J.
Green Chemistry, 2013 , vol. 15, # 5 p. 1218 - 1225
反应条件
sodium hydride 1) glyme, ice cooling, 2) room temperature, 1 h; reflux, 1 h; Yield given. Multistep reaction. Further byproducts given;
参考文献
Chiu, Andrew A.; Gorby, R. Russel; Hancock, John E. H.; Hustedt, Eric J.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4313 - 4315
参考文献
Hoffmann,R.W. et al.
Chemische Berichte, 1974 , vol. 107, p. 3395 - 3407
反应条件
CuCN in diethyl ether T=0°C; 1 h; effect of methylcopper reagent structure on product distribution; Product distribution;
参考文献
Chounan, Yukiyasu; Horino, Hiroshi; Ibuka, Toshiro; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 8 p. 1953 - 1960
参考文献
Bischoff
Chemische Berichte, 1896 , vol. 29, p. 967
反应条件
carbon dioxide 1) CH3CN, room temp, platinum-anode, plumbum-cathode; Multistep reaction;
参考文献
Engels, Rainer; Smit, Cornelis J.; Tilborg, Wim J. M. van
Angewandte Chemie, 1983 , vol. 95, # 6 p. 502 - 503
