[1,2,3]噻二唑-5-羧酸乙酯合成路线 （共 7 条）
反应条件
thionyl chloride
T=0 - 60°C;
参考文献
Tripathy, Rabindranath; Ghose, Arup; Singh, Jasbir; Bacon, Edward R.; Angeles, Thelma S.; Yang, Shi X.; Albom, Mark S.; Aimone, Lisa D.; Herman, Joseph L.; Mallamo, John P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1793 - 1798
反应条件
1: 58 percent / NaOAc / ethanol; H2O
2: 67 percent / SOCl2 / 0 - 60 °C
View Scheme
参考文献
Tripathy, Rabindranath; Ghose, Arup; Singh, Jasbir; Bacon, Edward R.; Angeles, Thelma S.; Yang, Shi X.; Albom, Mark S.; Aimone, Lisa D.; Herman, Joseph L.; Mallamo, John P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1793 - 1798
反应条件
1: TFA / CH2Cl2; H2O / 20 °C
2: 58 percent / NaOAc / ethanol; H2O
3: 67 percent / SOCl2 / 0 - 60 °C
View Scheme
参考文献
Tripathy, Rabindranath; Ghose, Arup; Singh, Jasbir; Bacon, Edward R.; Angeles, Thelma S.; Yang, Shi X.; Albom, Mark S.; Aimone, Lisa D.; Herman, Joseph L.; Mallamo, John P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1793 - 1798
参考文献
Pain,D.L.; Slack,R.
Journal of the Chemical Society, 1965 , p. 5166 - 5176
反应条件
(i) aq. HCl, (ii) SOCl2; Multistep reaction;
参考文献
Raap,R.; Micetich,R.G.
Canadian Journal of Chemistry, 1968 , vol. 46, p. 1057 - 1063
反应条件
sodium hydroxide in methanol
T=0°C;
参考文献
Shafiee; Lalezari; Yazdani; Shahbazian; Partovi
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 2 p. 304 - 307
反应条件
hydrazine hydrate in methanol
参考文献
Pain,D.L.; Slack,R.
Journal of the Chemical Society, 1965 , p. 5166 - 5176
