6-噁-2-氮杂螺[3.4]辛烷草酸盐合成路线 （共 4 条）
反应条件
palladium on activated charcoal; ammonium formate in ethanol; water
T=50°C; 4.5 h; Inert atmosphere;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael
Patent: WO2013/11285 A1, 2013 ;
Location in patent: Page/Page column 57 ;
WO 2013/011285 A1
反应条件
1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 2.5 h / 1 - 10 °C
2: palladium on activated charcoal; ammonium formate / ethanol; water / 4.5 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael
Patent: WO2013/11285 A1, 2013 ;
WO 2013/011285 A1
反应条件
1: thionyl chloride / pyridine; dichloromethane / 4.25 h / 25 - 30 °C / |Inert atmosphere
2: triethylamine; boron trifluoride diethyl etherate / pyridine; dichloromethane / 0.67 h / -72 - 12 °C / |Inert atmosphere
3: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 2.5 h / 1 - 10 °C
4: palladium on activated charcoal; ammonium formate / ethanol; water / 4.5 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael
Patent: WO2013/11285 A1, 2013 ;
WO 2013/011285 A1
反应条件
1: triethylamine; boron trifluoride diethyl etherate / pyridine; dichloromethane / 0.67 h / -72 - 12 °C / |Inert atmosphere
2: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 2.5 h / 1 - 10 °C
3: palladium on activated charcoal; ammonium formate / ethanol; water / 4.5 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael
Patent: WO2013/11285 A1, 2013 ;
WO 2013/011285 A1
