5,8a-二甲基-3,4,8,8a-四氢-1,6-(2H,7H)-萘二酮合成路线 （共 11 条）
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile
T=70°C; 0.0333333 h;
参考文献
Ates, Ali; Gautier, Arnaud; Leroy, Bernard; Plancher, Jean-Marc; Quesnel, Yannick; Vanherck, Jean-Christophe; Marko, Istvan E.
Tetrahedron, 2003 , vol. 59, # 45 p. 8989 - 8999
反应条件
triethylamine; benzoic acid in xylene
22 h; Heating;
参考文献
Liu, Hsing-Jang; Wynn, Hla
Canadian Journal of Chemistry, 1986 , vol. 64, p. 658 - 666
反应条件
1: in methanol
4 h; Heating;
2: in benzene
16 h; Heating; Further stages.;
参考文献
Kawanami, Hajime; Ikushima, Yutaka
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5147 - 5150
反应条件
toluene-4-sulfonic acid in benzene
28 h; Heating;
参考文献
Banerjee, Ajoy K.; Hurtado S., Hector E.
Tetrahedron, 1985 , vol. 41, # 15 p. 3029 - 3032
反应条件
1: 1,4-diazabicyclooctane (DABCO) / 1,2-dimethoxy-ethane / 12 h / Ambient temperature
2: triethylamine, benzoic acid / xylene / 24 h / Heating
View Scheme
参考文献
Ziegler, Frederic E.; Hwang, Ki-Jun; Kadow, John F.; Klein, Scott I.; Pati, Uttam K.; Wang, Tein-Fu
Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4573 - 4579
反应条件
1: 1,4-diazabicyclooctane (DABCO) / 1,2-dimethoxy-ethane / 12 h / Ambient temperature
2: triethylamine, benzoic acid / xylene / 24 h / Heating
View Scheme
参考文献
Ziegler, Frederic E.; Hwang, Ki-Jun; Kadow, John F.; Klein, Scott I.; Pati, Uttam K.; Wang, Tein-Fu
Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4573 - 4579
反应条件
1: With aluminum oxide
T=20°C; Michael addition; 0.166667 h;
2: With pyrrolidine
Robinson annulation; 0.116667 h; microwave irradiation;
参考文献
Takatori, Kazuhiko; Nakayama, Masayasu; Futaishi, Naoko; Yamada, Saori; Hirayama, Shinobu; Kajiwara, Masahiro
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 4 p. 455 - 457
反应条件
lithium aluminium tetrahydride; carbon tetrabromide; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; ethylene glycol; triphenylphosphine
1.) benzene, reflux; 2.) ether, 0 deg C, then Rt, 2 h; 3.) CH2Cl2, Rt, 30 min; 4.) toluene, Rt, 30 min, then reflux 30 min; Yield given. Multistep reaction;
参考文献
Inayama; Shimizu; Ohkura; Akita; Oishi; Iitaka
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 3 p. 712 - 717
反应条件
1: CCl4, Ph3P
2: Bu3SnH
View Scheme
参考文献
Inayama, Seiichi; Shimizu, Nobuko; Ohkura, Tamiko; Akita, Hiroyuki; Oishi, Takeshi; Iitaka, Yoichi
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2660 - 2663
反应条件
1: LiAlH4
2: CCl4, Ph3P
3: Bu3SnH
View Scheme
参考文献
Inayama, Seiichi; Shimizu, Nobuko; Ohkura, Tamiko; Akita, Hiroyuki; Oishi, Takeshi; Iitaka, Yoichi
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2660 - 2663
