1,2,3,4-四氢异喹啉-1-羧酸合成路线 （共 9 条）
反应条件
hydrogen; platinum on activated charcoal in acetic acid T=25°C; P=45004.5 Torr; 24 h;
参考文献
Paal, Tihamer A.; Forro, Eniko; Liljeblad, Arto; Kanerva, Liisa T.; Fueloep, Ferenc
Tetrahedron Asymmetry, 2007 , vol. 18, # 12 p. 1428 - 1433
反应条件
1: aqueous H2SO4 2: platinum; acetic acid / Hydrogenation View Scheme
参考文献
Solomon
Journal of the Chemical Society, 1947 , p. 129
反应条件
sodium hydroxide in tert-butyl alcohol 24 h; Ambient temperature;
参考文献
Shuman; Rothenberger; Campbell; Smith; Gifford-Moore; Gesellchen
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 314 - 319
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0 deg C, 1 h; 60 deg C, 16 h;
参考文献
Liu, Lee Tai; Lin, Ya-Chuan; Wang, Chia-Lin J.; Lin, Mei-Shey; Yen, Su-Chen; Chen, Hsiao-Jen
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1335 - 1338
反应条件
thionyl chloride 1 h; Heating;
参考文献
Paal, Tihamer A.; Forro, Eniko; Liljeblad, Arto; Kanerva, Liisa T.; Fueloep, Ferenc
Tetrahedron Asymmetry, 2007 , vol. 18, # 12 p. 1428 - 1433
参考文献
Kawase, Masami; Okada, Youichi; Miyamae, Hiroshi
Heterocycles, 1998 , vol. 48, # 2 p. 285 - 294
反应条件
1: 54 percent / SOCl2 / 1 h / Heating 2: 80 percent / lipase B from Candida antarctica; dipropylamine; water / acetonitrile; toluene / 192 h / 25 °C / Enzymatic reaction View Scheme
参考文献
Paal, Tihamer A.; Forro, Eniko; Liljeblad, Arto; Kanerva, Liisa T.; Fueloep, Ferenc
Tetrahedron Asymmetry, 2007 , vol. 18, # 12 p. 1428 - 1433
反应条件
sodium hydroxide in tert-butyl alcohol
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
反应条件
1: 1.) thionyl chloride, 2.) triethylamine / 1.) reflux, overnight, 2.) water, RT, 2 h
2: K2CO3 / CH2Cl2 / Ambient temperature
3: 1 N aq. NaOH / methanol / 4 h / Ambient temperature
View Scheme
参考文献
Stanton; Gruenfeld; Babiarz; Ackerman; Friedmann; Yuan; Macchia
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1267 - 1277
