6,7,8,9-四氢-5H-环庚并[b]吡啶-N-氧化物合成路线 （共 6 条）
反应条件
bismuth(III) chloride; indium in methanol T=20°C; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Yoo, Byung Woo; Choi, Jin Woo
Synthetic Communications, 2009 , vol. 39, # 19 p. 3550 - 3554
反应条件
dihydrogen peroxide; methyltrioxorhenium (VII) in dichloromethane; water
T=20°C; 12 h;
参考文献
Kaiser, Stefan; Smidt, Sebastian P.; Pfaltz, Andreas
Angewandte Chemie - International Edition, 2006 , vol. 45, # 31 p. 5194 - 5197
反应条件
dihydrogen peroxide; sodium carbonate in chloroform; acetic acid
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
1: 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine With dihydrogen peroxide; acetic acid in water
T=70°C; 12 h; Inert atmosphere;
2: sodium carbonate in chloroform
T=20°C; 2 h;
参考文献
Hardin Narayan, Alison R.; Sarpong, Richmond
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 1 p. 70 - 78
反应条件
1: With trifluoroacetic anhydride in dichloromethane
T=20°C; Cooling with ice;
2: With potassium carbonate in dichloromethane
参考文献
GLAXO GROUP LIMITED; BERTINATO, Peter; FICHMAN, Merav; GHOSH, Shomir; LIN, Jian; SEGAL, Dalia; ZHANG, Zhaoda
Patent: WO2010/49366 A1, 2010 ;
Location in patent: Page/Page column 71-72 ;
WO 2010/049366 A1
反应条件
1.1: acetic anhydride / 36 h / 90 °C / Inert atmosphere
1.2: 24 h / 70 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
View Scheme
参考文献
Hardin Narayan, Alison R.; Sarpong, Richmond
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 1 p. 70 - 78
