1: With dihydrogen peroxide in water; acetic acid
T=70°C; 16 h;
2: With sodium carbonate in chloroform
T=20°C; 2 h;
3: With methanol; water; acetic anhydride; potassium carbonate
more than 3 stages;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/96444 A2, 2006 ;
Location in patent: Page/Page column 127-128 ;
WO 2006/096444 A2