2-苯基咪唑并[1,2-a]吡啶合成路线 （共 59 条）
反应条件
copper diacetate; palladium diacetate in N,N-dimethyl-formamide T=120°C; 3 h; regioselective reaction;
参考文献
Synthesis, , # 2 p. 271 - 276
反应条件
1: 88 percent / benzene / Ambient temperature; room temp., 8-10 days or reflux, 30-40 h 2: 91 percent / aq.NaOH View Scheme
参考文献
Anisimova, V. A.; Avdyunina, N. I.; Pozharskii, A. F.; Simonov, A. N.; Talanova, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 4 p. 409 - 417
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 4 p. 528 - 537
反应条件
1: 83 percent / N-iodosuccinimide / acetonitrile / 0.5 h / 20 °C 2: 85 percent / Pd(PPh3)4; aq. NaOH / 1,2-dimethoxy-ethane / 6 h / 75 °C View Scheme
参考文献
Enguehard, Cecile; Renou, Jean-Louis; Collot, Valerie; Hervet, Maud; Rault, Sylvain; Gueiffier, Alain
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6572 - 6575
参考文献
Almirante,L. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 305 - 312
反应条件
1.1: 85 percent / acetic acid / H2O / 4 h / 50 - 55 °C
2.1: MeI / CH2Cl2 / 24 h / 20 °C
2.2: H2O / 4 h / Heating
3.1: 86 percent / aq. KOH / ethanol / 8 h / Heating
View Scheme
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
sodium nitrite in water; acetic acid
cooling;
参考文献
Salgado-Zamora, Hector; Velazquez, Manuel; Mejia, Daniel; Campos-Aldrete; Jimenez, Rogelio; Cervantes, Humberto
Heterocyclic Communications, 2008 , vol. 14, # 1-2 p. 27 - 32
反应条件
nitric acid; trifluoroacetic acid
1 h; Ambient temperature;
参考文献
Saldabol, N. O.; Popelis, Yu. Yu.; Mazheika, I. B.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 7 p. 1403 - 1404
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 7 p. 1558 - 1559
反应条件
chlorine in tetrachloromethane
T=0 - 5°C; 1.5 h;
参考文献
Bal'on, Ya. G.; Shul'man, M. D.; Smirnov, V. A.; Yukhomenko, M. M.; Yukhomenko, M. A.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 7.2 p. 1352 - 1356
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 7 p. 1566 - 1571
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 2 h;
参考文献
Marhadour, Sophie; Bazin, Marc-Antoine; Marchand, Pascal
Tetrahedron Letters, 2012 , vol. 53, # 3 p. 297 - 300
