(R)-2-氧代四氢呋喃-3-基氨基甲酸苄酯合成路线 （共 6 条）
反应条件
1: With sodium hydrogencarbonate in water T=0 - 20°C; 18.5 h; Inert atmosphere; 2: With hydrogenchloride in water pH=2; Inert atmosphere;
参考文献
King, Amber M.; Salome, Christophe; Dinsmore, Jason; Salome-Grosjean, Elise; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Kohn, Harold
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4815 - 4830
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 1 h; Title compound not separated from byproducts.;
参考文献
Lall, Manjinder S.; Karvellas, Constantine; Vederas, John C.
Organic Letters, 1999 , vol. 1, # 5 p. 803 - 806
反应条件
hydrogen fluoride; methyl iodide in acetic acid 15 h;
参考文献
Wolfe, Saul; Wilson, Marie-Claire; Cheng, Ming-Huei; Shustov, Gennady V.; Akuche, Christiana I.
Canadian Journal of Chemistry, 2003 , vol. 81, # 8 p. 937 - 960
反应条件
1: 74 percent / aq. NaHCO3 / 22 h / 20 °C 2: 20 percent / HF; MeI / acetic acid / 15 h View Scheme
参考文献
Henneboehle, Marco; Le Roy, Pierre-Yves; Hein, Matthias; Ehrler, Rudolf; Jaeger, Volker
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 4 p. 451 - 467
反应条件
1.1: aq. HCl / tetrahydrofuran / 5 h / 20 °C 2.1: aq. NaIO4 / tetrahydrofuran / 36 h / 20 °C 2.2: 11 mg / CrO3; AcOH / 4.5 h View Scheme
参考文献
Henneboehle, Marco; Le Roy, Pierre-Yves; Hein, Matthias; Ehrler, Rudolf; Jaeger, Volker
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 4 p. 451 - 467
反应条件
hydrogen bromide; acetic acid 6 h; Title compound not separated from byproducts;
参考文献
Henneboehle, Marco; Le Roy, Pierre-Yves; Hein, Matthias; Ehrler, Rudolf; Jaeger, Volker
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 4 p. 451 - 467
