3,5-二甲基金刚胺盐酸盐合成路线 （共 12 条）
反应条件
1: With sodium hydroxide in diethylene glycol 6 h; Reflux; 2: With water in dichloromethane; diethylene glycol T=20°C; 0.25 h; 3: With hydrogenchloride in ethyl acetate T=0 - 30°C; 6 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2011/125062 A1, 2011 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With water; sodium hydroxide in methanol 12 h; Reflux; 2: With hydrogenchloride in methanol; n-heptane T=60 - 65°C; Product distribution / selectivity;
参考文献
MERZ PHARMA GMBH andamp; CO. KGAA; GOLD, Markus-Rene; JIRGENSONS, Aigars; HUBER, Florian, Anton, Martin
Patent: WO2010/69555 A1, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
hydrogenchloride pH=6; Gas phase;
参考文献
Ren, Huixue; Ying, Hanjie; Ouyang, Pingkai; Lin, Jimao; Jing, Liu
Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5107 - 5110
反应条件
hydrogenchloride; sodium hydroxide; urea in water
参考文献
Merz and Co.
Patent: US4122193 A1, 1978 ;
反应条件
1: With thiourea in ethanol; acetic acid 8 h; Heating / reflux; 2: With sodium hydroxide in water; toluene T=45 - 55°C; 0.25 h; 3: With hydrogenchloride; water Product distribution / selectivity; more than 3 stages;
参考文献
HEXAL AG
Patent: EP1820792 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: With acetic acid; zinc T=20°C; 2 h; 2: With acetyl chloride in methanol T=40°C; 16 h; Heating;
参考文献
Huard, Kim; Lebel, Helene
Chemistry - A European Journal, 2008 , vol. 14, # 20 p. 6222 - 6230
反应条件
1: With sulfuric acid T=60 - 80°C; 8 - 10 h; 2: With polyethylene glycol; sodium hydroxide T=120 - 130°C; 12.5 - 20 h; 3: With hydrogenchloride in isopropyl alcohol T=0 - 85°C; 0.5 - 0.666667 h; Product distribution / selectivity;
参考文献
MSN LABORATORIES LIMITED
Patent: WO2009/57140 A2, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62472 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: bromine / 12 h / Reflux 2: sulfuric acid / 12 h 3: sodium hydroxide / water; ethylene glycol / 12 h / 150 °C 4: hydrogenchloride / pH 6 / Gas phase View Scheme
参考文献
Reddy, Jambula Mukunda; Prasad, Ganji; Raju, Veeramalla; Ravikumar, Mylavarapu; Himabindu, Vurumidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 268 - 269
反应条件
1: hydrogenchloride / water / 15 h / 25 - 30 °C 2: 8 h / 150 °C 3: hydrogenchloride / water / 100 - 105 °C View Scheme
参考文献
Reddy, Jambula Mukunda; Prasad, Ganji; Raju, Veeramalla; Ravikumar, Mylavarapu; Himabindu, Vurumidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 268 - 269
