7-溴-2,4-二氯噻吩并[3,2-d]嘧啶合成路线 （共 5 条）
反应条件
N,N-diethylaniline; trichlorophosphate T=150°C; 5 h;
参考文献
Korea Institute of Science and Technology
Patent: US2012/277424 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 97 percent / bromine / acetic acid / 48 h / 110 °C 2: 64 percent / POCl3; N,N-diethylaniline / 3 h / Heating View Scheme
参考文献
CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng
Patent: WO2011/130628 A1, 2011 ;
WO 2011/130628 A1
反应条件
sulfuryl dichloride in dichloromethane; acetonitrile T=0°C; 24 h;
参考文献
Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo
Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611
反应条件
1.1: cyanic acid sodium salt / water; acetic acid / 5 h / 20 °C 1.2: 0 °C 2.1: bromine / acetic acid / 30 h / 110 °C 3.1: N,N-diethylaniline; trichlorophosphate / 5 h / 150 °C View Scheme
参考文献
Korea Institute of Science and Technology
Patent: US2012/277424 A1, 2012 ;
反应条件
1: sodium tetrahydroborate / ethanol; tetrahydrofuran / 1 h / 20 °C 2: chloranil / benzene / 3 h / Reflux View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; CHOI, Hwan Geun; HAH, Jung Mi; HAM, Young Jin; JUN, Eun Jin; LEE, Jung Hun; KIM, Hwan
Patent: WO2011/49332 A2, 2011 ;
WO 2011/049332 A2
Title/Abstract Full Text Show Details
Korea Institute of Science and Technology
Patent: US2012/277424 A1, 2012 ;
