反应条件
1: 68 percent / HCl(g) / 0 - 5 °C
2: 1.) NaH / 1.) THF, 2.) THF, reflux, 30 min
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 2 h
View Scheme
参考文献
Guzzi, Umberto; Ciabatti, Romeo; Padova, Giovanna; Battaglia, Franco; Cellentani, Mario; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1826 - 1832
