N-叔丁氧羰基-L-缬氨酸-O-硝基苯基酯合成路线 （共 4 条）
参考文献
Bodanszky,M. et al.
Journal of Organic Chemistry, 1973 , vol. 38, p. 3565 - 3570
反应条件
1: 85 percent / Et3N / tetrahydrofuran / 1 h 2: 92 percent / NaH / tetrahydrofuran / 36 h / Ambient temperature 3: 100 percent / CF3CO2H / CH2Cl2 / Ambient temperature 4: 1) ClCO2Bu-i, N-methylmorpholine / 1) THF, 0 deg C, 4 min, 2) THF, a) 0 deg C, 15 min, b) r.t., 1 h 5: 89 percent / H2 / 20percent Pd(OH)2/C / methanol / 4 h / 26 °C / 1520 Torr View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 459 - 470
反应条件
Multi-step reaction with 2 steps 1: 85 percent / Et3N / tetrahydrofuran / 1 h2: 92 percent / NaH / tetrahydrofuran / 36 h / Ambient temperature
参考文献
Bashiardes, George; Bodwell, Graham J.; Davies, Stephen G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 4 p. 459 - 470
反应条件
Multi-step reaction with 3 steps 1: 85 percent / Et3N / tetrahydrofuran / 1 h2: 92 percent / NaH / tetrahydrofuran / 36 h / Ambient temperature3: 100 percent / CF3CO2H / CH2Cl2 / Ambient temperature
参考文献
Bashiardes, George; Bodwell, Graham J.; Davies, Stephen G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 4 p. 459 - 470
