4-[(E)-2-(3,5-二羟基苯基)乙烯基]苯基乙酸酯合成路线 （共 18 条）
反应条件
1: 97 percent / SOCl2; benzotriazole / CH2Cl2 / 0.17 h
2: 59 percent / 1,3-bis-(2,6-diisopropylphenyl)imidazolinium chloride; N-methylmorpholine / Pd(OAc)2 / xylene / 3.5 h / 120 °C
3: 72 percent / NaI; trimethylsilyl chloride / CH2Cl2; acetonitrile / 0.25 h
View Scheme
参考文献
Andrus, Merritt B.; Liu, Jing
Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5811 - 5814
反应条件
in 2-methyl-2-butanol
T=40°C; Enzymatic reaction; regioselective reaction;
参考文献
Torres, Pamela; Poveda, Ana; Jimenez-Barbero, Jesus; Ballesteros, Antonio; Plou, Francisco J.
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 2 p. 807 - 813
反应条件
1: potassium carbonate
2: sodium hydroxide / ethanol
3: thionyl chloride / toluene
4: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
5: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: sodium hydroxide / ethanol
2: thionyl chloride / toluene
3: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
4: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: thionyl chloride / toluene
2: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
3: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
2: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
T=60°C; 0.75 h; Further byproducts.;
参考文献
Fragopoulou, Elizabeth; Nomikos, Tzortzis; Karantonis, Haralabos C.; Apostolakis, Constantinos; Pliakis, Emmanuel; Samiotaki, Martina; Panayotou, George; Antonopoulou, Smaragdi
Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 1 p. 80 - 89
反应条件
T=60°C; 0.75 h; Further byproducts.;
参考文献
Fragopoulou, Elizabeth; Nomikos, Tzortzis; Karantonis, Haralabos C.; Apostolakis, Constantinos; Pliakis, Emmanuel; Samiotaki, Martina; Panayotou, George; Antonopoulou, Smaragdi
Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 1 p. 80 - 89
