(R)-(+)-3-羟基-5-氧代-1-环戊烯-1-庚酸甲酯合成路线 （共 23 条）
反应条件
1: aq. phosphate buffer; dioxane / 30 h / pH 8 / Heating 2: 46 percent / PPL 3: 98 percent / guanidine View Scheme
参考文献
Murcia, M. Carmen; De La Herran, Gabriela; Plumet, Joaquin; Csaky, Aurelio G.
Synlett, 2007 , # 10 p. 1553 - 1556
反应条件
1: aq. phosphate buffer; dioxane / 30 h / pH 8 / Heating 2: 46 percent / PPL 3: 98 percent / guanidine View Scheme
参考文献
Murcia, M. Carmen; De La Herran, Gabriela; Plumet, Joaquin; Csaky, Aurelio G.
Synlett, 2007 , # 10 p. 1553 - 1556
反应条件
1: 1) CuCN / 2) THF, -78 deg C up to r.t. 2: n-Bu4NF / tetrahydrofuran View Scheme
参考文献
Tsujiyama; Ono; Yoshino; Okamoto; Sato
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4481 - 4484
反应条件
1: 1) CuCN / 2) THF, -78 deg C up to r.t. 2: n-Bu4NF / tetrahydrofuran View Scheme
参考文献
Tsujiyama; Ono; Yoshino; Okamoto; Sato
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4481 - 4484
反应条件
(i) Al, (ii) AcOH; Multistep reaction;
参考文献
Sih; Heather; Sood; Price; Peruzzotti; Lee
Journal of the American Chemical Society, 1975 , vol. 97, # 4 p. 865 - 874
反应条件
(i) Al, (ii) AcOH; Multistep reaction;
参考文献
Sih; Heather; Sood; Price; Peruzzotti; Lee
Journal of the American Chemical Society, 1975 , vol. 97, # 4 p. 865 - 874
反应条件
1H-imidazole in N,N-dimethyl-formamide
参考文献
COSMO TECHNOLOGIES LTD.; Assandri, Alessandro; Moro, Luigi
Patent: US2013/202704 A1, 2013 ;
Location in patent: Paragraph 0068 ;
反应条件
2,6-dimethylpyridine in dichloromethane T=-78 - 20°C; silylation; 15 h;
参考文献
Wang, Yili; Wos, John A.; Dirr, Michelle J.; Soper, David L.; DeLong, Mitchell A.; Mieling, Glen E.; De, Biswanath; Amburgey, Jack S.; Suchanek, Eric G.; Taylor, Cynthia J.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 945 - 952
反应条件
in N,N-dimethyl-formamide; Petroleum ether
参考文献
Merrell Dow Pharmaceuticals
Patent: US5055592 A1, 1991 ;
反应条件
1.1: 88 percent / Et3N / tetrahydrofuran / 20 °C 2.1: n-BuLi; CuCN; MeLi / diethyl ether / 3.08 h / -78 - 0 °C 2.2: diethyl ether; hexane / 0.33 h / -78 °C 3.1: pyridinium p-toluenesulfonate / acetone; H2O / 4 h / 20 °C 4.1: 89 percent / porcine pancreatic lipase; NaCl; CaCl2 / H2O; tetrahydrofuran / 0.5 h / Enzymatic reaction; pH 7.1 View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
