(R)-(+)-3-(叔丁基二甲基硅氧基)-5-氧代-1-环戊烯基-1-己酸甲酯合成路线 （共 13 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide
参考文献
COSMO TECHNOLOGIES LTD.; Assandri, Alessandro; Moro, Luigi
Patent: US2013/202704 A1, 2013 ;
Location in patent: Paragraph 0068 ;
反应条件
2,6-dimethylpyridine in dichloromethane T=-78 - 20°C; silylation; 15 h;
参考文献
Wang, Yili; Wos, John A.; Dirr, Michelle J.; Soper, David L.; DeLong, Mitchell A.; Mieling, Glen E.; De, Biswanath; Amburgey, Jack S.; Suchanek, Eric G.; Taylor, Cynthia J.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 945 - 952
反应条件
9-borabicyclo[3.3.1]nonane dimer; water; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; Addition;
参考文献
Roberts, Stanley M.; Gabriella Santoro; Guyot, Thierry
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 17 p. 2437 - 2438
反应条件
1: 97 percent / pyridine / CH2Cl2 / 0 °C 2: 74 percent / 9-BBN; Cs2CO3; H2O / (dppf)PdCl2 / tetrahydrofuran; dimethylformamide / 0 °C View Scheme
参考文献
Johnson, Carl R.; Braun, Matthew P.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 11014 - 11015
反应条件
1: 50 percent / 50 °C / acrylic supported Candida antarctica lipase B 2: imidazole / dimethylformamide 3: PDC / CH2Cl2 4: 93 percent / I2, pyridine / CCl4 5: 1.) 9-BBN-H, 2.) Cs2CO3, bis(diphenylphosphino)ferrocene palladium(II) chloride, Ph3As / 1.) THF, RT, 4 h, 2.) THF, H2O View Scheme
参考文献
Johnson, Carl R.; Braun, Matthew P.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 11014 - 11015
反应条件
1: imidazole / dimethylformamide 2: PDC / CH2Cl2 3: 93 percent / I2, pyridine / CCl4 4: 1.) 9-BBN-H, 2.) Cs2CO3, bis(diphenylphosphino)ferrocene palladium(II) chloride, Ph3As / 1.) THF, RT, 4 h, 2.) THF, H2O View Scheme
参考文献
Johnson, Carl R.; Braun, Matthew P.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 11014 - 11015
反应条件
1: PDC / CH2Cl2 2: 93 percent / I2, pyridine / CCl4 3: 1.) 9-BBN-H, 2.) Cs2CO3, bis(diphenylphosphino)ferrocene palladium(II) chloride, Ph3As / 1.) THF, RT, 4 h, 2.) THF, H2O View Scheme
参考文献
Johnson, Carl R.; Braun, Matthew P.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 11014 - 11015
反应条件
1: imidazole / dimethylformamide 2: PDC / CH2Cl2 3: 93 percent / I2, pyridine / CCl4 4: 1.) 9-BBN-H, 2.) Cs2CO3, bis(diphenylphosphino)ferrocene palladium(II) chloride, Ph3As / 1.) THF, RT, 4 h, 2.) THF, H2O View Scheme
参考文献
Johnson, Carl R.; Braun, Matthew P.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 11014 - 11015
反应条件
in N,N-dimethyl-formamide; Petroleum ether
参考文献
Merrell Dow Pharmaceuticals
Patent: US5055592 A1, 1991 ;
反应条件
1: lipase (PPL) 2: quanidine / methanol / 0 °C 3: 84 percent / imidazole; Et3N / dimethylformamide View Scheme
参考文献
Rodriguez, Ana R.; Spur, Bernd W.
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4575 - 4579
