2-氨基-1-(4-溴苯基)-1-乙醇合成路线 （共 7 条）
反应条件
1: With potassium hydroxide; sodium tetrahydroborate in methanol T=20°C; 0.2 h; 2: With water; sodium hydrogencarbonate
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2007/78523 A2, 2007 ;
Location in patent: Page/Page column 69 ;
WO 2007/078523 A2
反应条件
1: With sodium hexamethyldisilazane in tetrahydrofuran T=0 - 25°C; 14 h; 2: With water in tetrahydrofuran T=25°C; 5 h; regioselective reaction;
参考文献
Murugan, Andiappan; Kadambar, Vasantha Krishna; Bachu, Sreekanth; Rajashekher Reddy; Torlikonda, Venkatarao; Manjunatha, Sulur G.; Ramasubramanian, Sridharan; Nambiar, Sudhir; Howell, Gareth P.; Withnall, Jane
Tetrahedron Letters, 2012 , vol. 53, # 43 p. 5739 - 5741
反应条件
potassium hydroxide in isopropyl alcohol T=100°C; Microwave irradiation;
参考文献
Baruwati, Babita; Polshettiwar, Vivek; Varma, Rajender S.
Tetrahedron Letters, 2009 , vol. 50, # 11 p. 1215 - 1218
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Papanikos, Alexandra; Eklund, John; Jackson, W. Roy; Kenche, Vijaya B.; Campi, Eva M.; Robertson, Alan D.; Jarrott, Bevyn; Beart, Philip M.; Munro, Fiona E.; Callaway, Jennifer K.
Australian Journal of Chemistry, 2002 , vol. 55, # 3 p. 205 - 212
反应条件
sodium tetrahydroborate
参考文献
Boyer; Ellzey
Journal of Organic Chemistry, 1958 , vol. 23, p. 127
反应条件
lithium aluminium tetrahydride
参考文献
Dornow; Theidel
Chemische Berichte, 1955 , vol. 88, p. 1267,1274
反应条件
sodium acetate in methanol
参考文献
Poos,G.I. et al.
Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272
