2,2,4-三甲基-1,2-二氢-喹啉-7-胺合成路线 （共 5 条）
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5696130 A1, 1997 ;
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethyl acetate; ethanol / 6 h / Ambient temperature
2: 82 percent / MgSO4, 4-tert-butylcatechol, I2 / 8 h / Heating
3: TFA / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 91 percent / 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / Ambient temperature
2: 100 percent / H2 / 10percent Pd/C / ethyl acetate; ethanol / 6 h / Ambient temperature
3: 82 percent / MgSO4, 4-tert-butylcatechol, I2 / 8 h / Heating
4: TFA / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
trifluoroacetic acid in dichloromethane
3 h; Ambient temperature;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 82 percent / MgSO4, 4-tert-butylcatechol, I2 / 8 h / Heating
2: TFA / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
