反应条件
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2: lithium chloride / Pd2(PPh3)2Cl2 / N,N-dimethyl-formamide / 4 h / 100 °C
3: hydrogen / palladium 10 on activated carbon / ethanol / 1 h / 20 °C
4: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 72 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen
Patent: WO2011/59850 A1, 2011 ;