6-溴-2-甲基-1H-苯并[de]异喹啉-1,3(2H)-二酮合成路线 （共 11 条）
反应条件
1: With [2,2']bipyridinyl; nickel dichloride; zinc in N,N-dimethyl-formamide T=70°C; 6 h; 2: With dihydrogen peroxide in N,N-dimethyl-formamide T=30 - 40°C; 0.5 h;
参考文献
Adonin; Ryabinin; Starichenko
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 6 p. 861 - 865
反应条件
1: With [2,2']bipyridinyl; nickel dichloride; zinc in N,N-dimethyl-formamide T=70°C; 6 h; 2: With hydrogenchloride in N,N-dimethyl-formamide T=30 - 40°C; 0.5 h; Title compound not separated from byproducts;
参考文献
Adonin; Ryabinin; Starichenko
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 6 p. 861 - 865
参考文献
Wang, Xin; Chen, Zhuo; Tong, Linjiang; Tan, Shaoying; Zhou, Wei; Peng, Ting; Han, Kun; Ding, Jian; Xie, Hua; Xu, Yufang
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 477 - 486
反应条件
in water
T=20°C; 2.5 h;
参考文献
Lu, Erhu; Peng, Xiaojun; Song, Fengling; Fan, Jiangli
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 2 p. 255 - 257
反应条件
1: bromine; potassium hydroxide / water / 2.67 h / 20 - 60 °C
2: ethanol / 4 h / Reflux
View Scheme
参考文献
Shahid, Mohammad; Srivastava, Priyanka; Misra, Arvind
New Journal of Chemistry, 2011 , vol. 35, # 8 p. 1690 - 1700
反应条件
1: sodium dichromate; acetic acid / 4 h / 75 °C
2: bromine; potassium hydroxide / water / 2.67 h / 20 - 60 °C
3: ethanol / 4 h / Reflux
View Scheme
参考文献
Shahid, Mohammad; Srivastava, Priyanka; Misra, Arvind
New Journal of Chemistry, 2011 , vol. 35, # 8 p. 1690 - 1700
反应条件
1: With [2,2']bipyridinyl; nickel dichloride; zinc in N,N-dimethyl-formamide
T=70°C; 6 h;
2: With dihydrogen peroxide in N,N-dimethyl-formamide
T=30 - 40°C; 0.5 h;
参考文献
Adonin; Ryabinin; Starichenko
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 6 p. 861 - 865
反应条件
1: With [2,2']bipyridinyl; nickel dichloride; zinc in N,N-dimethyl-formamide
T=70°C; 6 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=30 - 40°C; 0.5 h; Title compound not separated from byproducts;
参考文献
Adonin; Ryabinin; Starichenko
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 6 p. 861 - 865
反应条件
in methanol
T=130°C; sealed tube; other temperature; Rate constantKineticsThermodynamic data;
参考文献
Plakidin, V. L.; Vostrova, V. N.
Journal of Organic Chemistry USSR (English Translation), 1983 , p. 2273 - 2281
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 12 p. 2591 - 2600
反应条件
in methanol
T=130°C; 18 h; sealed tube;
参考文献
Plakidin, V. L.; Vostrova, V. N.
Journal of Organic Chemistry USSR (English Translation), 1983 , p. 2273 - 2281
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 12 p. 2591 - 2600
