(2Z)-2-羟基-4-氧代-4-苯基-2-丁烯酸甲酯合成路线 （共 3 条）
反应条件
1: oxalic acid dimethyl ester With sodium methylate in methanol
Claisen condensation; 0.25 h;
2: acetophenone in methanol
T=30°C; Claisen condensation; 0.0833333 h; Microwave irradiation;
参考文献
Reddy, Tummala R. K.; Li, Chan; Guo, Xiaoxia; Myrvang, Helene K.; Fischer, Peter M.; Dekker, Lodewijk V.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2080 - 2094
反应条件
sodium methylate in methanol
3 h; Reflux;
参考文献
Zhuang, Chunlin; Miao, Zhenyuan; Wu, Yuelin; Guo, Zizhao; Li, Jin; Yao, Jianzhong; Xing, Chengguo; Sheng, Chunquan; Zhang, Wannian
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 567 - 577
反应条件
1: in methanol
3 h; Reflux;
2: With hydrogenchloride in water
参考文献
Zhuang, Chunlin; Miao, Zhenyuan; Zhu, Lingjian; Dong, Guoqiang; Guo, Zizhao; Wang, Shengzheng; Zhang, Yongqiang; Wu, Yuelin; Yao, Jianzhong; Sheng, Chunquan; Zhang, Wannian
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9630 - 9642
