5-甲基恶唑-4-甲酸甲酯合成路线 （共 7 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=0 - 20°C;
参考文献
Amaike, Kazuma; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Journal of the American Chemical Society, 2012 , vol. 134, # 33 p. 13573 - 13576
反应条件
iodine; triethylamine; triphenylphosphine in dichloromethane 16 h;
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Tetrahedron, 2004 , vol. 60, # 18 p. 3967 - 3977
反应条件
1: 43 percent / Rh2(OAc)4 / 1,2-dichloro-ethane / Heating 2: 45 percent / triphenylphosphine; iodine; triethylamine / CH2Cl2 / 16 h View Scheme
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Tetrahedron, 2004 , vol. 60, # 18 p. 3967 - 3977
反应条件
(i) imidazole, Et3N, THF, (ii) /BRN= 3537963/; Multistep reaction;
参考文献
Henneke,K.-W. et al.
Liebigs Annalen der Chemie, 1979 , p. 1370 - 1387
反应条件
hydrogenchloride in methanol
参考文献
Suzuki,M. et al.
Journal of Organic Chemistry, 1973 , vol. 38, p. 3571 - 3575
反应条件
sodium hydroxide in methanol T=40°C; 4 h;
参考文献
Doss, Raymond M.; Marques, Michael A.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9074 - 9079
反应条件
diisobutylaluminium hydride in hexane; dichloromethane
T=0°C; 0.5 h; Inert atmosphere;
参考文献
Meng, Lingkui; Kamada, Yuko; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10048 - 10051
Angew. Chem., 2013 , vol. 125, # 38 p. 10232 - 10235,4
