1-氨基-3-苯基-2-丙酮盐酸盐(1:1)合成路线 （共 5 条）
参考文献
Maeda; Suzuki; Iwasaki; Matsumoto; Iwasawa
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 7 p. 2536 - 2543
反应条件
1: 51 percent / HCl
2: 64 percent / HCl
View Scheme
参考文献
Maeda; Suzuki; Iwasaki; Matsumoto; Iwasawa
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 7 p. 2536 - 2543
反应条件
1: 82 percent / Et3N
2: 51 percent / HCl
3: 64 percent / HCl
View Scheme
参考文献
Maeda; Suzuki; Iwasaki; Matsumoto; Iwasawa
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 7 p. 2536 - 2543
反应条件
sodium methylate; sodium in methanol; ethyl acetate
参考文献
Smith Kline and French Laboratories Limited
Patent: US4238494 A1, 1980 ;
反应条件
sodium methylate in methanol
1.) 60 deg C, 45 min, 2.) reflux, 30 min;
参考文献
Young; Mitchell; Brown; Ganellin; Griffiths; Jones; Rana; Saunders; Smith; Sore; Wilks
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 656 - 671
