6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉合成路线 （共 16 条）
反应条件
trimethylamine-N-oxide; (N,N,N-trimethyl-2-(5-oxo-4,6-bis(trimethylsilyl)cyclopenta[c]pyrrol-2-(1H,3H,5H)-yl)ethanaminium) iron tricarbonyl; hydrogen in water T=100°C; P=7500.75 Torr; 14 h; AutoclaveInert atmosphere; Reagent/catalyst;
参考文献
Merel, Delphine S.; Elie, Margaux; Lohier, Jean-Francois; Gaillard, Sylvain; Renaud, Jean-Luc
ChemCatChem, 2013 , vol. 5, # 10 p. 2939 - 2945
反应条件
1: With trifluoroacetic acid in toluene T=140°C; Pictet-Spengler cyclisation; 0.5 h; Microwave irradiation; 2: With sodium hydroxide in water pH=8; Cooling;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
trifluoroacetic acid T=72°C; 1.2 h;
参考文献
Yokoyama, Akihiro; Ohwada, Tomohiko; Shudo, Koichi
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 611 - 617
反应条件
(-)-sparteine in tetrahydrofuran; diethyl ether; cyclohexane T=-76°C; 1 h;
参考文献
Chrzanowska, Maria; Sokolowska, Joanna
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1435 - 1440
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-100 - -95°C; 0.25 h;
参考文献
Bradsher, Charles K.; Hunt, David A.
Journal of Organic Chemistry, 1981 , vol. 46, # 2 p. 327 - 330
反应条件
1: toluene / 2 h / Heating 2: CF3CO2H / toluene / 2 h / Heating View Scheme
参考文献
Gitto, Rosaria; Barreca, Maria Letizia; De Luca, Laura; De Sarro, Giovambattista; Ferreri, Guido; Quartarone, Silvana; Russo, Emilio; Constanti, Andrew; Chimirri, Alba
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 197 - 200
反应条件
trifluoroacetic acid T=80°C; Pictet-Spengler reaction; 5 h; Inert atmosphereneat (no solvent);
参考文献
Chowdappa, Nagaraja; Sherigara, Bailur Sheena; Augustine, John Kallikat; Areppa, Kummara; Mandal, Ashis Baran
Synthesis, 2010 , # 17 art. no. Z09910SS, p. 2949 - 2956
反应条件
1: toluene / 3 h / Heating 2: TFA / 90 h / Heating View Scheme
参考文献
Aubry, Sylvain; Pellet-Rostaing, Stephane; Faure, Rene; Lemaire, Marc
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 1 p. 139 - 148
反应条件
1: 72 percent / P2O5, POCl3 / xylene / 6 h / Heating 2: 74 percent / acetic acid, NaBH4 / methanol / 1.) RT, 1 h, 2.) 50 deg C, 4 h View Scheme
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
反应条件
1: 85 percent / 20percent NaOH / diethyl ether / Ambient temperature 2: 72 percent / P2O5, POCl3 / xylene / 6 h / Heating 3: 74 percent / acetic acid, NaBH4 / methanol / 1.) RT, 1 h, 2.) 50 deg C, 4 h View Scheme
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
